1
عمومی::
ایمونوگلوبولین انسانی
The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region, typically that of a human immunoglobulin, and thus will typically comprise a human Fc region.
[00285] The chimeric antibody was produced by combining the variable regions of the light chain (L chain) and the heavy chain (H chain) of mouse antibody Ta1505 with, respectively, the constant regions of the L chain and the H chain of human immunoglobulin (Ig) G1(?).
The VL gene was fused in-frame to a human immunoglobulin kappa L-chain constant region (CL) gene (the amino acid sequence and the nucleotide sequence thereof are defined in SEQ-ID-NO: 52 and SEQ-ID-NO: 53, respectively), and the VH gene was fused in-frame to a human immunoglobulin gamma-1 H-chain constant region (CH) gene (the amino acid sequence and the nucleotide sequence thereof are defined in SEQ-ID-NO: 54 and SEQ-ID-NO: 55, respectively), such that no mutation or defect should occur at each binding site.
The 5'-ends of the VL gene and the VH gene were fused in-frame to, respectively, a signal sequence derived from the human immunoglobulin kappa L-chain gene (the amino acid sequence and the nucleotide sequence thereof are defined in SEQ-ID-NO: 56 and SEQ-ID-NO: 57, respectively) and a signal sequence derived from the human immunoglobulin gamma-1 H-chain gene (the amino acid sequence and the nucleotide sequence thereof are defined in SEQ-ID-NO: 58 and SEQ-ID-NO: 59, respectively), such that no mutation or defect should occur at each binding site.
واژگان شبکه مترجمین ایران